Which class of immunoglobulin possesses 10 antigenic binding sites?

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Study for the Success! In Clinical Laboratory Science – Immunology Test. Prepare with flashcards and multiple choice questions, each question offers hints and explanations. Get ready for your exam!

Multiple Choice

Which class of immunoglobulin possesses 10 antigenic binding sites?

Explanation:
Valency of an antibody comes from how its molecules are assembled. IgM is produced as a pentamer, five basic IgM units joined together (often with a J chain). Each unit has two antigen-binding sites, so stacking five units yields ten binding sites in one IgM molecule. That high number helps IgM effectively cross-link antigens and activate complement early in an immune response. The other classes are typically monomeric (IgG, IgD) with two binding sites, and even though secretory IgA can be a dimer with four sites, none reach ten. Hence the class with ten antigen-binding sites is IgM.

Valency of an antibody comes from how its molecules are assembled. IgM is produced as a pentamer, five basic IgM units joined together (often with a J chain). Each unit has two antigen-binding sites, so stacking five units yields ten binding sites in one IgM molecule. That high number helps IgM effectively cross-link antigens and activate complement early in an immune response. The other classes are typically monomeric (IgG, IgD) with two binding sites, and even though secretory IgA can be a dimer with four sites, none reach ten. Hence the class with ten antigen-binding sites is IgM.

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