In rheumatoid arthritis, the serologically detectable antibody is primarily of the class:

Unlock all questions

This demo includes only 20 questions. Upgrade to access hundreds of questions, flashcards, exam simulations, and disable ads.

Full question bankExam simulationsFlashcards
From $24.99Unlock all

Study for the Success! In Clinical Laboratory Science – Immunology Test. Prepare with flashcards and multiple choice questions, each question offers hints and explanations. Get ready for your exam!

Multiple Choice

In rheumatoid arthritis, the serologically detectable antibody is primarily of the class:

Explanation:
Rheumatoid factor is the autoimmune antibody most classically associated with rheumatoid arthritis, and the majority of RF detected in RA is of the IgM class. IgM is a pentamer, which makes it particularly effective at cross-linking IgG molecules to form immune complexes. These RF-IgM–IgG complexes activate complement and deposit in the synovium, driving inflammation and joint damage that characterize RA. While other antibodies can be present—in particular, anti-CCP antibodies are often IgG—the common serologic marker tested for RA is IgM rheumatoid factor.

Rheumatoid factor is the autoimmune antibody most classically associated with rheumatoid arthritis, and the majority of RF detected in RA is of the IgM class. IgM is a pentamer, which makes it particularly effective at cross-linking IgG molecules to form immune complexes. These RF-IgM–IgG complexes activate complement and deposit in the synovium, driving inflammation and joint damage that characterize RA. While other antibodies can be present—in particular, anti-CCP antibodies are often IgG—the common serologic marker tested for RA is IgM rheumatoid factor.

More Multiple Choice Questions
Subscribe

Get the latest from Examzify

You can unsubscribe at any time. Read our privacy policy