In multiple myeloma, malignant cells are derived from which lineage?

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Study for the Success! In Clinical Laboratory Science – Immunology Test. Prepare with flashcards and multiple choice questions, each question offers hints and explanations. Get ready for your exam!

Multiple Choice

In multiple myeloma, malignant cells are derived from which lineage?

Explanation:
Malignant cells in this disease are mature plasma cells, the antibody-secreting end stage of the B lymphocyte lineage. Plasma cells originate from B cells that have been activated and differentiated; in multiple myeloma, a single clone of these plasma cells expands in the bone marrow and produces a monoclonal immunoglobulin. T lymphocytes and monocytes come from different lineages and do not become plasma cells, so they are not the source of the malignant cells in this condition.

Malignant cells in this disease are mature plasma cells, the antibody-secreting end stage of the B lymphocyte lineage. Plasma cells originate from B cells that have been activated and differentiated; in multiple myeloma, a single clone of these plasma cells expands in the bone marrow and produces a monoclonal immunoglobulin. T lymphocytes and monocytes come from different lineages and do not become plasma cells, so they are not the source of the malignant cells in this condition.

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