For an antibody-coated antigen to be phagocytized, which antibody region binds to receptors on phagocytes?

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Study for the Success! In Clinical Laboratory Science – Immunology Test. Prepare with flashcards and multiple choice questions, each question offers hints and explanations. Get ready for your exam!

Multiple Choice

For an antibody-coated antigen to be phagocytized, which antibody region binds to receptors on phagocytes?

Explanation:
Engagement of Fc receptors on phagocytes by the antibody’s Fc region drives phagocytosis. The Fc portion is the constant, stem-like part of the antibody that interacts with Fc receptors on macrophages and neutrophils, signaling them to engulf the opsonized particle. The Fab region, by contrast, is responsible for binding the antigen itself, not for receptor binding on phagocytes. The hinge region is merely a flexible connector between Fab and Fc, and the variable region determines antigen specificity but does not mediate phagocyte receptor binding.

Engagement of Fc receptors on phagocytes by the antibody’s Fc region drives phagocytosis. The Fc portion is the constant, stem-like part of the antibody that interacts with Fc receptors on macrophages and neutrophils, signaling them to engulf the opsonized particle. The Fab region, by contrast, is responsible for binding the antigen itself, not for receptor binding on phagocytes. The hinge region is merely a flexible connector between Fab and Fc, and the variable region determines antigen specificity but does not mediate phagocyte receptor binding.

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