Diagnosis of group A streptococci infection is indicated by the presence of which antibody?

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Study for the Success! In Clinical Laboratory Science – Immunology Test. Prepare with flashcards and multiple choice questions, each question offers hints and explanations. Get ready for your exam!

Multiple Choice

Diagnosis of group A streptococci infection is indicated by the presence of which antibody?

Explanation:
Anti-DNase B reflects the immune response to a group A Streptococcus infection because GAS secretes DNase B and the body makes antibodies against it. This antibody appears after infection and tends to stay elevated longer than anti-streptolysin O, making it a reliable marker for recent GAS exposure, including cases where infection was in the skin or where initial tests were negative. Among the options, this is the best indicator of GAS infection. Anti-protein A is associated with Staphylococcus aureus, not GAS. Anti-beta-toxin and C-reactive protein are not specific indicators of a GAS infection.

Anti-DNase B reflects the immune response to a group A Streptococcus infection because GAS secretes DNase B and the body makes antibodies against it. This antibody appears after infection and tends to stay elevated longer than anti-streptolysin O, making it a reliable marker for recent GAS exposure, including cases where infection was in the skin or where initial tests were negative. Among the options, this is the best indicator of GAS infection. Anti-protein A is associated with Staphylococcus aureus, not GAS. Anti-beta-toxin and C-reactive protein are not specific indicators of a GAS infection.

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