Cell-mediated immunity is primarily mediated by which cell type?

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Study for the Success! In Clinical Laboratory Science – Immunology Test. Prepare with flashcards and multiple choice questions, each question offers hints and explanations. Get ready for your exam!

Multiple Choice

Cell-mediated immunity is primarily mediated by which cell type?

Explanation:
Cell-mediated immunity is driven by T lymphocytes. Helper T cells play a central coordinating role by recognizing antigen with MHC class II on antigen-presenting cells and releasing cytokines such as IL-2 and IFN-γ that activate cytotoxic T cells and macrophages. This orchestration enables the targeted killing of infected or abnormal cells, which is the hallmark of the cell-mediated response. B cells and their plasma cell descendants handle antibody production (humoral immunity), while dendritic cells primarily act as antigen-presenting cells to activate T cells rather than executing the effector response themselves.

Cell-mediated immunity is driven by T lymphocytes. Helper T cells play a central coordinating role by recognizing antigen with MHC class II on antigen-presenting cells and releasing cytokines such as IL-2 and IFN-γ that activate cytotoxic T cells and macrophages. This orchestration enables the targeted killing of infected or abnormal cells, which is the hallmark of the cell-mediated response. B cells and their plasma cell descendants handle antibody production (humoral immunity), while dendritic cells primarily act as antigen-presenting cells to activate T cells rather than executing the effector response themselves.

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