Bruton disease is characterized by the absence of which immunoglobulins?

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Study for the Success! In Clinical Laboratory Science – Immunology Test. Prepare with flashcards and multiple choice questions, each question offers hints and explanations. Get ready for your exam!

Multiple Choice

Bruton disease is characterized by the absence of which immunoglobulins?

Explanation:
Bruton agammaglobulinemia occurs when B cell maturation is blocked due to a BTK gene defect, so the body can’t make antibody-producing cells. As a result, circulating B cells are virtually absent and immunoglobulins of all classes (IgG, IgA, IgM) are severely reduced or absent. That panhypoglobulinemia explains why the statement describing the absence of all immunoglobulins best fits Bruton disease. In contrast, other scenarios describe selective deficiencies or elevations (for example, isolated IgA deficiency or raised IgE), which are not characteristic of Bruton.

Bruton agammaglobulinemia occurs when B cell maturation is blocked due to a BTK gene defect, so the body can’t make antibody-producing cells. As a result, circulating B cells are virtually absent and immunoglobulins of all classes (IgG, IgA, IgM) are severely reduced or absent. That panhypoglobulinemia explains why the statement describing the absence of all immunoglobulins best fits Bruton disease. In contrast, other scenarios describe selective deficiencies or elevations (for example, isolated IgA deficiency or raised IgE), which are not characteristic of Bruton.

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